Mitochondria are the essential energy-generating powerhouses that provide our cells with the energy of life. However, their malfunction has a dark side. …more

Our seventh MRC PPU alumni interview is with Elton Zeqiraj, ex-PhD student who was jointly supervised by Dario Alessi and Daan van Aalten. …more

PI3K and Akt inhibitors are being evaluated in clinical trials for the treatment of human tumours including breast cancer that display driver mutations that inappropriately elevate the PI3K/Akt signalling pathway. Despite initial promise, the majority of these tumours rapidly evolve to resist the PI3K/Akt pathway therapy.  …more

Work in the Alessi lab in the MRC PPU has been geared towards understanding how mutations in LRRK2 impair its biological functions and cause Parkinson’s. …more

Esther Sammler, a former PhD student with Dario Alessi and consultant neurologist in Dundee has been awarded an Academic Health Sciences Partnership in Tayside (AHSP) Clinical Fellowship which is aimed at promoting translational research. …more

Yosua Adi Kristariyanto, a 4th year PhD student in Yogesh Kulathu’s lab, won the EMBO Journal Poster Award at the recent FASEB Conference on Ubiquitin and Cellular Regulation. The six-day conference held at Big Sky, Montana, USA was a platform for scientists across the world to meet and share recent findings in the ubiquitin field. …more

Researchers in the laboratory of Dr. Satpal Virdee have published the first example of genetically encodable aminooxy functionality, which can be installed site-selectively into recombinant proteins using genetic code expansion technology. …more

Satpal Virdee has been awarded a BBSRC Responsive Mode award of £650,000 allowing his lab to further develop technology they pioneered that enables the activity-based profiling of E3 ligases. …more

Our sixth alumni interview is with Anna Zagorska, ex-MRC PPU PhD student in Dario Alessi's group. Click the MRC PPU Alumni Interview icon on the top of our website, or here to read the interview. …more

The American Society for Biochemistry and Molecular Biology (ASBMB) have conducted a major in-depth interview with Davie Douglas: honorary member of the MRC PPU who for nearly the last 20 years has been the main airport taxi driver for our research staff and their guests.  …more