Lab Member | Kei Sakamoto

Postdoctoral Researcher

Kei Sakamoto
Past Lab Member

Current position: Head of Diabetes Research at the Nestle Institute of Health Sciences in Lausanne Switzerland

Previous position: Programme Leader in MRC Protein Phosphorylation Unit

Publications generated while in the lab:

Sakamoto, K., Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanovic, A., Alessi, D. R. and Bertrand, L. (2006). Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab. 290, pp. E780-8

Alessi, D. R., Sakamoto, K. and Bayascas, J. R. (2006). LKB1-dependent signaling pathways. Annu Rev Biochem. 75, pp. 137-63

Bayascas, J. R., Sakamoto, K., Armit, L., Arthur, J. S. and Alessi, D. R. (2006). Evaluation of approaches to generation of tissue-specific knock-in mice. J Biol Chem. 281, pp. 28772-81

McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. and Alessi, D. R. (2005). Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 24, pp. 1571-83

Mora, A., Sakamoto, K., McManus, E. J. and Alessi, D. R. (2005). Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart. FEBS Lett. 579, pp. 3632-8

Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Grahame Hardie, D., Ashworth, A. and Alessi, D. R. (2005). Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 24, pp. 1810-20

Sakamoto, K., Goransson, O., Hardie, D. G. and Alessi, D. R. (2004). Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab. 287, pp. E310-7

Dimopoulos, N., Watson, M., Sakamoto, K. and Hundal, H. S. (2006). Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J. 399, pp. 473-481

Hardie, D. G. and Sakamoto, K. (2006). AMPK: A key sensor of fuel and energy status in skeletal muscle. Physiology. 21, pp. 48-60

Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. and Hundal, H. S. (2005). Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle. Diabetes. 54, pp. 3161-8

Country of Origin: Japan