Miratul Muqit, Neurologist and Programme Leader at the MRC-PPU, has today been awarded over £90,000 by Parkinson's UK to fund research which could shed light on the molecular mechanisms underlying Parki …more

A collaborative effort spearheaded by Alejandro Rojas-Fernandez and Lina Herhaus, from the Hay (GRE) and Sapkota (MRC-PPU) labs respectively, has led to the publication of a methodology paper in Scientific Reports for rapidly generating endog …more

The Wellcome Trust has awarded Miratul Muqit an Enhancement Award to support a Postdoctoral Fellowship to investigate molecular mechanisms of Parkinson's disease.

The 3-year fellowship will build on ground breaking studies from the Mu …more

The deubiquitylase OTUB1 is ubiquitously expressed and is known to impact key cellular processes, from TGFÃ_Â_ and p53 signalling to DNA damage repair, by targeting a multitude of substrates both in the cytoplasm and nucleus. Until now it was not kno …more

Autophagy is a cell protective pathway that delivers unwanted, damaged or toxic components to the lysosome for degradation and recycling. It essentially prevents the cell from becoming a junkyard. Under most circumstances autophagy is a very benefici …more

Ubiquitylation regulates diverse cellular processes and this versatility is made possible because polyubiquitin chains of eight different linkage types can be assembled. Differently linked polyubiquitin chains couple to functionally distinct outcomes …more

Research in the Alessi lab has been focused on understanding how mutations that truncate the C-terminal non-catalytic moiety of a protein kinases termed TTBK2 (tau tubulin kinase 2) cause the inherited, autosomal dominant, spinocerebellar ataxia  …more

Ana Perez-Oliva a postdoc working in the Alessi lab on a collaborative project with Ian Hickson at Janssen Research & Development, was interested to explore the function of an unstudied deubiquitylase enzyme termed USP45 that is overexpressed in  …more

Marija Maric, who just completed her PhD studies in Karim Labib's group, has received the 2014 Howard Elder Prize for her discovery that the end of chromosome replication is regulated by ubiquitylation. Marija's award-winning PhD work was support …more

Huei-Ting Yang, a Ph.D. Student in Philip Cohen's lab from 2004-2008 and Edmond Wong, a postdoc in Daan van Aalten's lab and then Philip Cohen's lab from 2007-2009 were married in September in two ceremonies held in Taiwan and the UK. Huei-Ti …more