The ability of cells to move is crucial for many biological processes during development, and for normal tissue growth and repair. Cancer cells can usurp normal cellular processes and make them hyperactive, which leads to inappropriate cell movement that can contribute to metastasis. Understanding the molecular processes that regulate cell migration could uncover novel therapeutic targets against diseases such as cancer. …more

Derailment of the PI3K signalling network contributes to many human diseases including cancer.

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Research by Rosalia Fernandez-Alonso, a post-doctoral investigator in Dr. Greg Findlay’s lab in the MRC PPU, will be published in and featured on the cover of the July edition of the journal EMBO Reports. …more

Please note that the deadline for applying for these projects is 2nd June. These positions are also open to EU and non-EU applicants. It is expected the student would be able to take up the studentship in Autumn 2017. …more

Being able to selectively and rapidly degrade target proteins in cells is desirable in research and therapeutics.

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The Affinity-directed PROtein Missile (AdPROM) system, described by the Sapkota lab in Open Biology, combines the CRISPR/Cas9 genome editing technology and proteolysis to achieve a robust degradation of potentially any endogenous protein in cells. …more

Two Sapkota lab PhD students, Luke Fulcher and Luke Hutchinson, won prizes for best posters at the sixth annual PiCLS symposium held at the West Park Conference Centre on 17th October, 2016. …more

On 5 November, 2015 Sam Strickson, who has been supervised by Philip Cohen, has successfully defended his PhD. Over the past 4 years Sam has performed groundbreaking research into the role of the ubiquitin system in regulating the Interleukin 1 signa …more

Agne Kazlauskaite, a PhD student in Miratul Muqit and Dario Alessi's labs, has been awarded the 2015 Dundee Prize for Cell and Molecular Biology for her seminal contributions to the mechanistic understanding of how the Parkinson's disease ass …more

A collaborative effort spearheaded by Alejandro Rojas-Fernandez and Lina Herhaus, from the Hay (GRE) and Sapkota (MRC-PPU) labs respectively, has led to the publication of a methodology paper in Scientific Reports for rapidly generating endog …more