Two Sapkota lab PhD students, Luke Fulcher and Luke Hutchinson, won prizes for best posters at the sixth annual PiCLS symposium held at the West Park Conference Centre on 17th October, 2016. …more

On 5 November, 2015 Sam Strickson, who has been supervised by Philip Cohen, has successfully defended his PhD. Over the past 4 years Sam has performed groundbreaking research into the role of the ubiquitin system in regulating the Interleukin 1 signa …more

Agne Kazlauskaite, a PhD student in Miratul Muqit and Dario Alessi's labs, has been awarded the 2015 Dundee Prize for Cell and Molecular Biology for her seminal contributions to the mechanistic understanding of how the Parkinson's disease ass …more

A collaborative effort spearheaded by Alejandro Rojas-Fernandez and Lina Herhaus, from the Hay (GRE) and Sapkota (MRC-PPU) labs respectively, has led to the publication of a methodology paper in Scientific Reports for rapidly generating endog …more

The deubiquitylase OTUB1 is ubiquitously expressed and is known to impact key cellular processes, from TGFÃ_Â_ and p53 signalling to DNA damage repair, by targeting a multitude of substrates both in the cytoplasm and nucleus. Until now it was not kno …more

â€â€_Many congratulations to Gerrit Daubner, a postdoctoral researcher working in Dario Alessi's group, who has been awarded a prestigious personal long-term EMBO F …more

Congratulations to Lina Herhaus and Mazin Al-Salihi, of Gopal Sapkota's lab, for publishing a paper in Open Biology that describes how USP15 regulates the BMP pathway by deubiquitylating the type I BMP receptor, ALK3.



BMPs bel …more

Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8. In the canonical pathway, this triggers the  …more

Congratulations to Lina Herhaus, PhD student in Gopal Sapkota's lab, on being a recipient of the 2013 Tim Hunt Prize for Cell Biology for her work on elucidating the role of OTUB1 in the TGF-beta pathway.

The Tim Hunt prize for Cell Bi …more

Lina Herhaus, PhD student in Gopal Sapkota's lab, has published a paper on the role of OTUB1 in TGFÃ_Â_ signalling in Nature Communications.

The TGFÃ_Â_ signalling pathway controls plethora of cellular functions during embryogenesis a …more