Recent studies have revealed that mutations within the Tau tubulin Kinase 2 (TTBK2) cause a serious autosomal dominant inherited movement disorder termed spinocerebellar ataxias type 11 (SCA11) [1, 2]. SCA11 is characterised by progressive cerebellar …more
News
Princess Anne, the Princess Royal, visited the MRC Protein Phosphorylation Unit on April 19 in her role as the President of Tenovus, a Scottish cancer charity. The Princess met John Rouse, one of the Unit's Programme Leaders, who was recently awa …more
Miratul Muqit, a Wellcome Intermediate Fellow working with Dario Alessi, has been appointed a Consultant Neurologist at Ninewells Hospital in Dundee. Miratul was the first clinician to be appointed to the MRC-PPU and now becomes the first to reach th …more
The PI 3-kinase-mTOR signalling pathway is activated in the majority of human tumours and there is great interest in assessing whether inhibitors of PI 3-kinase or mTOR kinase would have efficacy in treating cancers in which this pathway is over acti …more
A few years ago at the beginning of her PhD Laura Pearce identified novel components of the mTOR complex 2 (mTORC2) that she termed Protor-1 and Protor-2. Laura found that Protor isoforms interacted with the mTORC2 component Rictor. Protor-1 and Prot …more
Beatrice Filippi and Paola de los Heros MRC Unit postdocs working in Dario Alessi's lab have reevaluated the role of the MO25 scaffolding protein, that Jerome Boudeau - a previous postdoc now running a lab in Montpellier - discovered was a key compon …more
Hugh Nimmo, the first postdoctoral fellow of Unit Director Philip Cohen, has been elected a Fellow of the Royal Society of Edinburgh. Hugh worked in Philip's laboratory from 1973 to 1976 on a grant funded by the British Diabetic Association (now call …more
Autosomal dominant missense mutations within the gene encoding for the Leucine-Rich Repeat protein Kinase 2 (LRRK2) predispose humans to develop Parkinson's disease (PD). Little is understood about how LRRK2 is regulated, or how it functions, or how …more
Dr. John Rouse, a Programme Leader at the Medical Research Council (MRC) Protein Phosphorylation Unit in the College of Life Sciences at the University of Dundee has been awarded the 2011 Tenovus Medal.
The …more
The …more
