Cullin-RING ligases (CRLs) are multi-subunit ubiquitin E3 enzymes, which ligate the small modifier ubiquitin to other cellular proteins. CRLs are modular complexes containing a core catalytic unit, which is combined with variable substrate-specific a …more

The MRC Protein Phosphorylation Unit and the SCottish Institute of ceLL Signalling (SCILLS) have merged into the MRC Protein Phosphorylation and Ubiquitylation Unit.

The new Unit will still retain the MRC-PPU brand name. Its scientists wil …more

Philip Cohen's research into the causes of inflammatory and autoimmune diseases has been boosted by the award of a grant of almost £1.7million from the Wellcome Trust to support his work over the next five years.



The grant …more

The MRC Protein Phosphorylation and Ubiquitylation Unit's flagship collaboration with pharmaceutical companies, termed Division of Signal Transduction Research (DSTT), is named by Health Science Scotland as their organisation of the month.

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MRC Protein Phosphorylation Unit PI, Vicky Cowling, will deliver a special Lister Prize Lecture today, Monday 4th March, to all researchers in the College of Life Sciences. In attendance will be the Chairman, Sir Alex Markham and the Director, Dr T …more

Professor Sir Philip Cohen, of the University of Dundee, will receive the highest award given by the Medical Research Council at a ceremony in the House of Commons today, Wednesday 27th February.

The Millenium Medal is the MRC's most prest …more

The Colworth Medal is awarded by the Biochemical Society to ‘an outstanding young British biochemist' under the age of 36. On Thursday 21 February the Biochemical Society ce …more

Gordon's hypertension syndrome is caused by mutations that increase expression of WNK1 protein kinase as well as specific missense mutations lying within a non-catalytic region of the WNK4 protein kinase. Patients with this condition suffer from high …more

We are delighted that our newest PI recruit, Yogesh Kulathu, will starting his independent laboratory within the MRC-PPU today, February 1st 2013. Until now Yogesh has been undertaking tremendous postdoctoral research in  …more

The Scottish Institute for Cell Signalling (SCILLS) and the MRC Protein Phosphorylation Unit will be merging into a new MRC Protein Phosphorylation and Ubiquitylation Unit at the end of March 2013.

To mark this important event, but also to …more