Research | Publications

Year

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E.

Principal Investigator(s):
Esther Sammler, Dario Alessi
2020
PubMed

Mitotic kinase anchoring proteins: the navigators of cell division.

Fulcher L, Sapkota GP

Principal Investigator(s):
Gopal Sapkota
2020
PubMed

Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H

Tachie-Menson T, Gázquez-Gutiérrez A, Fulcher LJ, Macartney TJ, Wood NT, Varghese J, Gourlay R, Soares RF, Sapkota GP

Principal Investigator(s):
Gopal Sapkota
2020
PubMed

Expanding the phenotype of the CDKL5 deficiency disorder: Are seizures mandatory?

MacKay CI1, Bick D, Prokop JW, Muñoz I, Rouse J, Downs J, Leonard H.

Principal Investigator(s):
John Rouse
2020
PubMed

A complex comprising C15ORF41 and Codanin-1- the products of two genes mutated in congenital dyserythropoietic anemia type I (CDA-I).

Shroff M, Knebel A, Toth R, Rouse J.

Principal Investigator(s):
John Rouse
2020
PubMed

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases.

Mathur S, Fletcher AJ, Branigan E, Hay RT, Virdee S.

Principal Investigator(s):
Satpal Virdee
2020
PubMed

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

Vieweg S, Mulholland K, Brauning B, Kacharia N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK

Principal Investigator(s):
Miratul Muqit
2020
PubMed

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation

Zhao, J-F., Rodger, C., Allen, G. F. G., Weidlich, S. & Ganley, I. G

Principal Investigator(s):
Ian Ganley
2020

Semi-automated quantitation of mitophagy in cells and tissues

Montava-Garriga, L., Singh, F., Ball, G. & Ganley, I

Principal Investigator(s):
Ian Ganley
2020
PubMed

The Identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

Zachari, M., Rainard, J. M., Pandarakalam, G. C., Robinson, L., Gillespie, J., Rajamanickam, M., Hamon, V., Morrison, A., Ganley, I. G. & McElroy, S. P

Principal Investigator(s):
Ian Ganley
2020
PubMed

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.

Hutchinson, L.D., Darling, N.J., Nicolaou, S, Gori, I., Squair, D., Cohen, P., Hill, C.S. and Sapkota, G.P

Principal Investigator(s):
Gopal Sapkota, Philip Cohen
2020
PubMed

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Waschbusch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D.R., Khan, A.R

Principal Investigator(s):
Dario Alessi
2020
PubMed

Advances in elucidating the function of protein kinase LRRK2 in normal cells and Parkinson's Disease

Taylor, M., Alessi, D.R

Principal Investigator(s):
Dario Alessi
2020
PubMed

Outstanding questions in mitophagy: what we do and do not know

Montava Garriga, L & Ganley

Principal Investigator(s):
Ian Ganley
2020
PubMed

HOIL-1, an atypical E3 ligase that controls MyD88 signalling by forming ester bonds between ubiquitin and components of the Myddosome

Cohen, P, Kelsall, IR, Nanda, SK & Zhang, J

Principal Investigator(s):
Philip Cohen
2020
PubMed

Phosphoproteomics Identifies a Bimodal EPHA2 Receptor Switch that Promotes Embryonic Stem Cell Differentiation

Fernandez-Alonso, R., Bustos, F., Budzyk, M., Helbig, A., Hukelmann, J., Lamond, A., Petsalaki, E. and Findlay, G.M.

Principal Investigator(s):
Greg Findlay
2020
PubMed

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover

Heo, S., Diering, G. H., Na, C. H., Nirujogi, R. S., Bachman, J. L., Pandey, A. and Huganir, R. L.

Principal Investigator(s):
Raja Nirujogi
2019
PubMed

Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria

Shears, M.J., Nirujogi, R. S., Swearingen, K.E., Renuse, S., Mishra, S., Panga, J.R., Mortiz, R.L., Pandey, A and Sinnis,P

Principal Investigator(s):
Raja Nirujogi
2019
PubMed

Integrated Transcriptomic and Proteomic Analysis of Primary Human Umbilical Vein Endothelial Cells

Madugundu, A.K., Na, C.H., Nirujogi, R.S., Renuse, S., Kim, K.P., Burns, K.H., Wilks, C., Lingmead, B., Ellis, S.E., Collado-Terres, L., Halushka, M.K., Kin, M.S. and Pandey, A

Principal Investigator(s):
Raja Nirujogi
2019
PubMed

OTULIN deficiency in ORAS causes cell type specific LUBAC degradation, dysregulated TNF signaling and cell death

Damgaard RB, Elliott PR, Swatek KN, Maher ER, Stepensky P, Elpeleg O, Komander D, and Berkun Y

Principal Investigator(s):
Kirby Swatek
2019
PubMed