Research | Publications

Year

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H.S., Yanatori, I., Gomez, R.C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D.R., Pfeffer, S.R

Principal Investigator(s):
Dario Alessi
2018
PubMed

Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1.

Osborne, J., Birchall, K., Tsagris, D.J., Lewis, S.J/, Smiljanic-Hurley, E., Taylor, D.L., Levy, A., Alessi, D.R., McIver, E.G.

Principal Investigator(s):
Dario Alessi
2018
PubMed

Regulation of proteasome assembly and activity in health and disease

Adrien Rousseau & Anne Bertolotti

Principal Investigator(s):
Adrien Rousseau
2018

USP45 and Spindly are part of the same complex implicated in cell migration

Conte C1,2, Griffis ER1,3, Hickson I4,5, Perez-Oliva AB6.

Principal Investigator(s):
Dario Alessi
2018
PubMed

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM

Principal Investigator(s):
Greg Findlay
2018
PubMed

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

De Cesare V, Johnson C, Barlow V, Hastie J, Knebel A, Trost M.

Principal Investigator(s):
Virginia De Cesare
2018
PubMed

Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells.

de Las Pozas A, Reiner T, De Cesare V, Trost M, Perez-Stable C.

Principal Investigator(s):
Virginia De Cesare
2018
PubMed

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. and Cohen, P

Principal Investigator(s):
Philip Cohen
2018
PubMed

PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP.

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C., and Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2018
PubMed

The DUF1669 domain of FAM83 family proteins anchor Casein Kinase 1 isoforms.

Fulcher, L. J., Bozatzi, P., Tachie-Menson, T., Cummins, T. D., Wu, K., Dunbar, K., Shrestha, S., Wood, N., Weidlich, S., Macartney, T. J., Varghese, J., Gourlay, R., Campbell, D. G., Dingwell, K. S., Smith, J. C., Bullock, A., and Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2018
PubMed

Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand.

McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG

Principal Investigator(s):
Ian Ganley, Miratul Muqit
2018
PubMed

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K. E., Tovell, H., Prescott, A. R. and Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2018
PubMed

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Ho, P. W., Ho, S. L., Chou, M. Y., Polinski, N. K., Martinez, T. N., Davies, P. and Alessi, D. R

Principal Investigator(s):
Dario Alessi, Paul Davies
2018
PubMed

LRRK2 kinase in Parkinson's disease

Alessi DR, Sammler E1

Principal Investigator(s):
Dario Alessi, Esther Sammler
2018
PubMed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S

Principal Investigator(s):
Satpal Virdee
2018
PubMed

PAWS1 controls Wnt signalling through association with casein kinase 1α

Bozatzi P, Dingwell KS, Wu KZ, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG1, Smith JC, Sapkota GP

Principal Investigator(s):
Gopal Sapkota
2018
PubMed

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

Ramachandran A, Vizán P, Das D, Chakravarty P, Vogt J, Rogers KW, Müller P, Hinck AP, Sapkota GP, Hill CS

Principal Investigator(s):
Gopal Sapkota
2018
PubMed

PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins TD, Wu KZL, Bozatzi P, Dingwell KS, Macartney TJ, Wood NT, Varghese J, Gourlay R, Campbell DG, Prescott A, Griffis E, Smith JC, Sapkota GP

Principal Investigator(s):
Gopal Sapkota
2018
PubMed

The anthelmintic drug niclosamide and its analogues activate the Parkinson's disease associated protein kinase PINK1

Erica Barini, Ageo Miccoli, Federico Tinarelli, Katie Mulholland, Hachemi Kadri, Farhat Khanim, Laste Stojanovski, Kevin D Read, Kerry Burness, Julian J Blow, Youcef Mehellou, Miratul MK Muqit

Principal Investigator(s):
Miratul Muqit
2018
PubMed

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong Y, Sonneville R, Wang B, Scheidt V, Meier B, Woglar A, Demetriou S, Labib K, Jantsch V, Gartner A

Principal Investigator(s):
Karim Labib
2018
PubMed