Understanding the mechanisms of Parkinson's disease remain a major biomedical challenge since the disease is on the rise and there remain no treatments that can cure or slow it down.

Over the last few years research in the Muqit lab h …more

Congratulations to Julien Peltier and Matthias Trost for receiving the Thermo Scientific TMT Research Awar …more

Congratulations are due to Marija Maric, who has just been awarded the Pontecorvo Prize for 2014, for her discovery that the end of chromosome replication is regulated by ubiquitylation and the p97 ATPase. Marija completed her PhD studies last year i …more

Miratul Muqit, Neurologist and Programme Leader at the MRC-PPU, has today been awarded over £90,000 by Parkinson's UK to fund research which could shed light on the molecular mechanisms underlying Parki …more

A collaborative effort spearheaded by Alejandro Rojas-Fernandez and Lina Herhaus, from the Hay (GRE) and Sapkota (MRC-PPU) labs respectively, has led to the publication of a methodology paper in Scientific Reports for rapidly generating endog …more

The Wellcome Trust has awarded Miratul Muqit an Enhancement Award to support a Postdoctoral Fellowship to investigate molecular mechanisms of Parkinson's disease.

The 3-year fellowship will build on ground breaking studies from the Mu …more

The deubiquitylase OTUB1 is ubiquitously expressed and is known to impact key cellular processes, from TGFÃ_Â_ and p53 signalling to DNA damage repair, by targeting a multitude of substrates both in the cytoplasm and nucleus. Until now it was not kno …more

Autophagy is a cell protective pathway that delivers unwanted, damaged or toxic components to the lysosome for degradation and recycling. It essentially prevents the cell from becoming a junkyard. Under most circumstances autophagy is a very benefici …more

Ubiquitylation regulates diverse cellular processes and this versatility is made possible because polyubiquitin chains of eight different linkage types can be assembled. Differently linked polyubiquitin chains couple to functionally distinct outcomes …more

Ana Perez-Oliva a postdoc working in the Alessi lab on a collaborative project with Ian Hickson at Janssen Research & Development, was interested to explore the function of an unstudied deubiquitylase enzyme termed USP45 that is overexpressed in  …more