Autophagy is a cell protective pathway that delivers unwanted, damaged or toxic components to the lysosome for degradation and recycling. It essentially prevents the cell from becoming a junkyard. Under most circumstances autophagy is a very benefici …more

Ubiquitylation regulates diverse cellular processes and this versatility is made possible because polyubiquitin chains of eight different linkage types can be assembled. Differently linked polyubiquitin chains couple to functionally distinct outcomes …more

Research in the Alessi lab has been focused on understanding how mutations that truncate the C-terminal non-catalytic moiety of a protein kinases termed TTBK2 (tau tubulin kinase 2) cause the inherited, autosomal dominant, spinocerebellar ataxia  …more

Ana Perez-Oliva a postdoc working in the Alessi lab on a collaborative project with Ian Hickson at Janssen Research & Development, was interested to explore the function of an unstudied deubiquitylase enzyme termed USP45 that is overexpressed in  …more

Marija Maric, who just completed her PhD studies in Karim Labib's group, has received the 2014 Howard Elder Prize for her discovery that the end of chromosome replication is regulated by ubiquitylation. Marija's award-winning PhD work was support …more

Huei-Ting Yang, a Ph.D. Student in Philip Cohen's lab from 2004-2008 and Edmond Wong, a postdoc in Daan van Aalten's lab and then Philip Cohen's lab from 2007-2009 were married in September in two ceremonies held in Taiwan and the UK. Huei-Ti …more

â€â€_Many congratulations to Gerrit Daubner, a postdoctoral researcher working in Dario Alessi's group, who has been awarded a prestigious personal long-term EMBO F …more

Matthias Trost has been awarded a BBSRC Industrial CASE studentship to develop novel methods for deep proteome analysis in collaboration with Thermo-Fisher Scientific.

This 4-year studentship which is only open to UK nationals or EU c …more

Philip Cohen received the 2014 Albert Einstein World Award of Science from the World Cultural Council at a ceremony at Aalto University Finland on 17 November 2014. The award was made by the World Cultural Council's Interdisciplinary Committee in …more

Miratul Muqit has been awarded a Parkinson's UK studentship to investigate the functions of the PINK1 kinase in Parkinson's disease.

This 3-year studentship will aim to identify and characte …more